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MOTS-c is a mitochondrial-derived peptide (MDP) that is attracting increasing interest in the fields of longevity, fat loss, insulin regulation, and athletic performance. Unlike most peptides derived from nuclear DNA, MOTS-c is encoded in mitochondria, providing unique metabolic effects at the cellular energetic level.
MOTS-c peptide benefits for metabolism (mitochondrial 12S rRNA open reading frame-c) is a 16-amino acid peptide encoded by mitochondrial DNA (mtDNA), not by nuclear DNA like most hormones and peptides. It plays a critical role in metabolic homeostasis, contributing to the regulation of glucose metabolism, fatty acid oxidation, and the cellular response to stress.
The body produces MOTS-c naturally, especially during fasting or exercise. However, exogenous administration (via peptide injection) amplifies these effects, especially in cases of metabolic dysfunction, aging, or intense training.
